Califia Bio Inc. provides medicinal chemistry expertise, compound design, synthesis, pharmacokinetic optimization and drug discovery services in collaborations with NIH funded academic research groups and small biotech companies. Our interests are in developing treatments for unmet therapeutic needs in the areas of neurodegenerative diseases, stroke, and inflammation. We are capable of taking projects from the stage of designing screening libraries, through hit-to-lead and lead optimization to the selection of compounds for clinical development. We collaborate with partners using their assays or our preferred third party assays for biology, pharmacology, ADME and toxicology. We have experience in guiding small companies towards the key features and properties that need to be improved to obtain potential clinical candidates and attract funding or partnering by large pharma.